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proved Regulatory approval can take a year, or take as long as ve or more years Furthermore, there is no guarantee that a candidate drug will be allowed to enter clinical trials Of 5,000 candidate drugs identi ed in the drug discovery process, only about ve or 01 percent receive regu latory approval for clinical trials Clinical trials are conducted in three phases, using an increasing num ber of subjects with each phase The goal in Phase I, which may extend a year or more, is to quantifying safety and dosage information in a few dozen healthy volunteers The focus of Phase II, which involves several hundred patients over the course of one or two years, is to document effec tiveness and side effects.

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4

where n is the outward normal to surface S. In (2.1.14), the surface integral at infinity gives the incident wave 7/Jinc(P)' For TE case of PEC, we apply (2.1.10) to get

{ ~(pl)

dSg(p, p )-8 (p)

87/J -

+ 7/Jinc (p )

Throw an exception from a method any time the method parameters, method state, or method operations are invalid The code that called the method can then catch the exception and proceed accordingly

(2.1.16)

dSg (p, p')

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Phase III, the most comprehensive and largest phase of clinical trials, is concerned with documenting the adverse reac tions as well as the effectiveness of the candidate drug on up to several thousand patients over a period of two or three years Given the time and number of patients involved, Phase III Clinical Trials typically account for 75 percent or more of a $200 to 800 million drug development budget Once clinical trials have demonstrated the safety, ef cacy, and clinical value of a drug, application for approval to market the candidate drug for a speci c purpose is made to the FDA This regulatory approval process typically lasts several years, depending on the strength of the clinical trial results.

~~ (P)

(2.1.17)

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This Building Along has two different sets of steps: one to use if you implemented printing and want to add exception handling to the printing code, and one to use if you did not implement printing but still want to try some exception handling If you want to implement exception handling in your printing, for the Purchase Tracker sample application: Open the MDI parent form (PTMDIParentWin) in the Code Editor Cut the code from the PrintPage event handler and copy it to a new ProcessPrintPage method Then call the new method from the PrintPage event handler The ProcessPrintPage method signature is as follows:

E S. Equation (2.1.17) is a surface integral equation because p and p' both belong to the same domain S. Equation (2.1.17) is Fredholm equation of the first kind. The source domain p and the field domain p' belong to the same domain. As p ---4 p', g(p, p') is large which means the matrix equation will have strong diagonal elements which makes (2.1.17) well conditioned usually. This is unlike Fredholm equation of the first kind in inverse scattering problems. In such inverse scattering problems, the source domain and the field domain are different. The matrix equation does not have large diagonal elements and the equation is often ill-conditioned. For TM problem of PEC, we apply boundary conditions (2.1.11). Then

{ ~(pl)

8g - - I dS7/J(P)-8 (p, p )

(2.1.18)

Private Sub ProcessPrintPage(ByVal e As _ SystemDrawingPrintingPrintPageEventArgs)

To get a surface integral equation, we let p' approach surface S. However, since 7/J(p') experiences a discontinuity of S from V to Vp which is also manifested in the fact that

~~ (p, p')

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